Objective To investigate the changes of multi-noninvasive indices, including endothelial function, arterial flexibility, carotid indima-media thickness (IMT), oxidative stress and inflammation in elderly patients with coronary artery disease. Methods Sixty-two male coronary artery disease patients (≥65 years old) with coronary artery stenosis ≥50% identified by coronary arteriography in our department from January 2008 to December 2011 were subjected in this study. They were divided into 2 groups according to the result of coronary angiography, that is, multiple vessel lesion group (n＝29) and single vessel lesion group (n＝33). Another 33 age-matched elderly male patients receiving coronary arteriography at the same period served as control. Before coronary arteriography, brachial-ankle pulse wave velocity (baPWV), ankle-brachial index (ABI) and carotid artery intima-media thickness (IMT) were measured, and serum level of nitric oxide (NO), endothelin-1 (ET-1), malondialdehyde (MDA) and high sensitive-C reactive protein (hs-CRP) were detected in all subjects. Results Significant differences were observed among the 3 groups in the levels of NO and ET-1, and baPWV, ABI and IMT (P＜0.05), but no difference was seen in the level of MDA and hs-CRP (P＞0.05). Moreover, carotid artery IMT became higher and higher with the increase of the number of diseased vessels. Logistic regression analysis showed that baPWV, smoking and diabetes mellitus were important factors for multiple vessel lesion in coronary artery disease (P＜0.05). Conclusion Among these multi-noninvasive indices, impaired endothelial dysfunction, the changes of the arterial flexibility as well as carotid artery IMT have close relation with the occurrence and development of coronary artery disease in elderly male patients. baPWV and carotid artery IMT may be predictors for the severity of coronary artery disease for the elderly.