Abstract:Objective To investigate the effects of different clinical factors on coagulation function in elderly patients with atrial fibrillation by detecting their coagulation factors. Methods Clinical data of 79 elderly patients with atrial fibrillation who were admitted to Department of Geriatrics, Bozhou Municipal People¢s Hospital from March 2011 to March 2012 were analyzed. Another 61 age-matched patients with normal sinus rhythm served as controls. Coagulation function was evaluated by prothrombin time (PT), activated partial thromboplastin time (APTT), and serum levels of fibrinogen (FG), D-Dimer (DDI) and glycosylated hemoglobin (HbAlc). Echocardiography was carried out for their left auricle internal dimension (LAID) and left ventricular ejection fraction (LVEF). Results The patients with atrial fibrillation had significantly higher levels on PT, APTT, FG and DDI than those with normal sinus rhythm (P<0.05). Logistic regression analysis indicated that LAID, LVEF, and HbAlc were predictive factors for DDI, so was LVEF for FG. Conclusion Elderly patients with atrial fibrillation are in a prothrombotic state, and anticoagulant therapy should be strengthened for them.