Objective To explore the diagnosis and treatment of radiation recall pneumonitis(RRP) in elderly. Methods The diagnosis and treatment of two cases of RRP induced by targeted medicines and antibiotics after radiotherapy for lung cancer was reviewed. Results Diagnosis of RRP induced by erlotinib and levofloxacin after thoracic radiotherapy was established for the two elderly patients with lung cancer. Symptomatic and radiographic improvement was observed after withdrawal of induced drugs and application of corticosteroids. Conclusions Doctor should pay attention to RRP on the aged patients treated with antibiotics and antineoplastics after radiotherapy.