Objective To investigate the clinical characteristics of invasive pulmonary mycosis(IPM) secondary to lung cancer. Methods The clinical data of 10 cases with IPM secondary to lung cancer in Beijing Institute of Respiratory Diseases from February 2010 to January 2012 were respectively analyzed. Results Average age of 10 patients was (64.5±14.7) years, and 5 cases were older than 70 years of age. There were 8 patients with non-small cell lung cancer, and 2 cases with small cell lung cancer. All the patients presented with clinical stage Ⅳ disease and received antitumor therapy. Definite IPM diagnosis was established in 7 cases and possible diagnosis in 3 cases. Aspergillus and candida were common pathogenic fungi in this group. The symptoms of IPM were mostly presented as dyspnea (8/10), fever (8/10), hemoptysis (5/10) and chest pain (5/10). The most frequent chest CT features included infiltrates and (or) consolidations (10/10), and cavities were found in 2 cases. All patients received antifungal therapy. Seven cases were improved and 3 cases died. Conclusion The elderly and advanced patients with lung cancer are more prone to secondary IPM after receiving antitummor therapy, which has a high mortality rate. Early diagnosis with prompt potent antifungal agents may be beneficial to these patients.