Peripheral artery disease (PAD) is more common, severe and more aggravated in the patients with diabetes mellitus. The conservative treatment of PAD should take into consideration two aspects: control of cardiovascular risk factors, and symptomatic treatment of intermitent claudication. Pentoxifylline, cilostazo, Sarpogrelate, and prostaglandins E can alleviate the peripheral ischemic symptoms, increase walking distance and improve the quality of life.