Objective To observe effect of beraprost sodium(BPS) on inflammatory factors in type 2 diabetic mellitus(T2DM) rats. Methods Thirty SD rats were randomly divided into control group, T2DM group, BPS treatment group. High-fat diet-fed was performed in DM and BPS rats to set T2DM model, and BPS of 0.6mg/(kg·d) was given to BPS rats. After 8 weeks, there were 6 rats left in each group, and the levels of interleukin-6(IL-6), tumor necrosis factorα(TNF-α), myeloperoxidase(MPO) and high sensitive-C reactive protein(hs-CRP) were determined in all groups. Results After 8 weeks of treatment, the levels of IL-6, TNF-α, MPO and hs-CRP were higher in T2DM rats than in control rats. In BPS rats, the levels of IL-6, TNF-α, MPO and hs-CRP were significantly lower than those in T2DM rats. Conclusion Beraprost sodium can significantly reduce the levels of inflammatory cytokines and alleviate the inflammation damage.