MicroRNA(miRNA) is one of small non-coding single-stranded RNAs, which, not only is an important regulatory molecule, but also participates in regulation of growth and aging. In this paper, we review some possible pathways and the related mechanisms of aging in which miRNA may be involved, such as the regulation of telomerase expression, p53 signaling pathway, Rb pathway, and the abnormal expression of the enzyme which directly regulates the synthesis of miRNA. This article provides an overview of research achievements in the relationship of miRNA and aging.