Objective To analyze the curative effect of linezolid and teicoplanin on aged patients with gram positive bacterium infection. Methods Clinical data of 58 cases [aged 84-98 years, mean(91.2±4.0) years] from January 2008 to August 2011 were retrospective analyzed. The patients were divided into linezolid group(30 cases) and teicoplanin group(28 cases) and standards of clinical evaluation (clarified as recovery, effective, proceeding and ineffective) and bacteriological evaluation (eliminated, presumptively eliminated, un-eliminated, substitutive, reinfective) were set to assess the curative effect as well as the adverse reaction of linezolid and teicoplanin. Results There was no no statistical difference in total clinical effective rate between linezolid and teicoplanin groups (93.3% vs 78.5%, P=0.103), while bacterial clear rate was significantly higher in linezolid group than in teicoplanin group (86.7% vs 53.6%, P＜0.05). The major adverse reaction of linezolid during treatment was thrombocytopenia and increased serum creatinine was observed in teicoplanin group. Conclusions Both linezolid and teicoplanin have good curative effects on aged patients that infected by gram positive cocci. Linezlid has superior clinical curative effect and bacteria clearance. It must be careful in medicine selection according to the indications, meanwhile pay more attention to platelets and serum creatinine monitoring.