Objective To investigate the association between smoking and coronary atherosclerosis. Methods Totally, 539 healthy male volunteers aged between 31 to 65 years were divided into smoking and non-smoking group and their cardio-ankle vascular index (CAVI) were examined using VaseraVS-1000 vascular screening device. Results CAVI positivity rate was significantly higher in smoking group than in non-smoking group (21.7% vs 5.3%; P＝0.000) . By 5-year age grouping, CAVI values of smoking group were all higher than those of the same age non-smoking group(P＜0.05). When grouping according to daily smoking amount, we found that the larger daily smoking amount was correlated with higher CAVI, and there were significant differences between groups(P＜0.05). When grouping according to the smoking history, CAVI ??increased in long time smoking group but no significant difference was found(P＞0.05). Grouping according to smoking index, CAVI increased with the smoking index. Conclusion CAVI is correlated with smoking.