Objective To investigate the association between two single nucleotide polymorphisms (SNPs＋45T＞G and SNPs＋276G＞T) of adiponectin gene and coronary artery diseases(CAD) in elderly patients without diabetes. Methods Coronary angiography were performed in 688 subjects ≥65 years without diabetes who were admitted to department of cardiology during November 2005 to December 2009. The subjects were divided into CAD group and control group according to coronary angiography. Genotype of two SNPs was measured by polymerase chain reaction/ligase detection reaction (PCR/LDR) assay. Results At＋45position, the risk rate of CAD in GG genotype was significantly increased compared with that in TT genotype(OR = 2.65, P＜0.01). At＋276position, the risk rate of CAD in GG or GT genotype was significantly higher than that in TT genotype(GG: OR = 2.36, P＜0.01; GT: OR =1.66, P＜0.05). Logistic regression analysis showed that GG genotype at SNPs＋45T＞G, GG genotype and GT genotype at SNPs＋276G＞T were independent risk factors of CAD. Furthermore, adiponectin gene SNPs＋45T＞G and SNPs＋276G＞T displayed strong linkage disequilibrium. GG genotype was shown at SNPs＋276G＞T when SNPs＋45T＞G genotype was GG and TT genotype was shown at SNPs＋45T＞G when SNPs＋276G＞T genotype was TT, that is GGGG and TTTT genotypes. Homozygous GGGG subjects showed a significantly higher risk of CAD(OR = 4.77, P＜0.01) than homozygous TTTT subjects. Conclusion In non-diabetic elderly subjects, those with GG genotype at SNPs＋45T＞G, GG genotype and GT genotype at SNPs＋276G＞T are the susceptible population of CAD.