Gelsolin is a member of gelsolin superfamily, which is an important actin binding protein. The gelsolin controls actin structure by severing filaments, capping filament ends and nucleating actin assembly. It occurs in a wide range of vertebrate, lower eukaryotic and plant cells, and its function is as variant as its biochemical activities. In addition to its role in actin filament remodeling, gelsolin has also other roles in several cellular processes, including cell motility, apoptosis control, and so on. In this paper, we introduced its biological features, structure, function, as well as its effect on actin binding in septic patients. The plasma gelsolin concentration is a predictor for severity and prognosis of septic patients. In addition, we introduced the therapeutic effects of exogenous gelsolin.