Objective This study was to discuss a new model of health education of osteoporosis. By setting up osteoporosis club as a health education platform, we studied the significance of this model in popularizing osteoporosis health knowledge in China. Methods We set up a club of osteoporosis, and adopted the unified management of the membership. A total of 1208 subjects, in which diagnosis of osteoporosis was established from January to May 2010, were enrolled, including 435 males, with an average age of (60.72±5.85) years, and 773 females, with an average age of (61.06±6.27) years. During the observation duration of 1 year, multiple activities of health education were carried out, including health education lecture once a month, outdoor sports such as climbing mountains and sunshine exposure. Comprehensive management considering dietary, sports and medication was also performed. All subjects filled in questionnaire to build a database, including osteoporosis cognitive level, pain degree evaluation, appraisal of life quality and bone mineral density(BMD) testing. All data were statistically analyzed by SPSS 11.5 software. Results After one year observation, cognitive level of osteoporosis was significantly raised [(10.07±0.27) vs (3.81±0.24) points]; VAS pain visual analogue scale significantly reduced [(1.56±0.24) vs (5.71±0.83) points]; appraisal of life quality significantly improved [(80.64±10.98) vs (66.38±7.72) points]; and the BMD of L2～4, Neck, Ward's, Troch significantly increased in both males and females respectively[males: (1.18±0.11) vs (1.02±0.22)g/cm2, (1.03±0.10) vs (0.89±0.15)g/cm2, (0.89±0.12) vs (0.76±0.09)g/cm2, (0.78±0.17) vs (0.62±0.12)g/cm2; females: (1.20±0.17) vs (1.01±0.18)g/cm2, (1.01±0.13) vs (0.88±0.05)g/cm2, (0.87±0.09) vs (0.74±0.11)g/cm2, (0.76±0.21) vs (0.60±0.07)g/cm2]. The differences reached the statistical significance(P＜0.05). Conclusion With population aging, the prevalence rate of osteoporosis increases. However, people have little awareness about this disease. It is significant to emphasize osteoporosis health education. Osteoporosis club, as a new model of health education, plays an important role in the comprehensive management of osteoporosis.