Objective To evaluate the change in Th1/Th2 related cytokines in the peripheral blood of patients with acute coronary syndrome(ACS),and to determine its roles in assessing the development of the lesion.Methods Sixty-four ACS patients were selected,including 22 patients with acute myocardial infarction(AMI),and 42 patients with unstable angina pectoris(UAP).Another 34 patients with stable angina pectoris(SAP) and 22 healthy persons served as controls.Serum concentrations of Th1/Th2 cytokines,such as IFN-γ,IL-2,IL-4,and IL-10 were measured.All patients underwent coronary angiography(CAG).Results The level of Th1 cytokines,including IFN-γ and IL-2,was elevated in patients with UAP and AMI compared to that with SAP and healthy controls.The level of Th2 cytokines,including IL-4 and IL-10,was decreased in patients with UAP and AMI compared to that with SAP and healthy controls.Compared with the type Ⅰ lesion,patients with type Ⅱ lesions showed higher in-gate percentage of Th1 cytokines and lower in-gate percentage of Th1 cytokines.Conclusion The imbalance of Th1/Th2 cytokines is correlated with the development of ACS,which could be useful for monitoring the stabilization of the lesion.?更多