Objective To investigate the relationship between the plasma level of B-type natriuretic peptide (BNP) and P-selectin(CD62P) in different types of coronary heart diseases (CHD) and its clinical significance. Methods A total of 105 subjects were divided into control group (group C,n=20) and CHD group according to the coronary angiography results. CHD group was further divided into stable angina pectoris (SA,n=21),unstable angina pectoris (UA,n=32) and acute myocardial infarction (AMI,n=32) subgroups according to the clinical diagnosis. Blood samples were taken from all patients before PCI. ELISA and flow cytometry were used to measure the plasma BNP and CD62P levels respectively.Results (1) Compared with group C,the plasma levels of BNP (283±42) ng/L vs (14±4) ng/L,P<0.05and CD62P (9.4±3.6)% vs (3.3±1.4)%,P<0.05raised obviously in CHD group. (2) There were significant differences in the plasma levels of BNP and CD62P among different CHD subgroups (F=21.5,13.6,P<0.01),with the levels highest in AMI subgroup. (3) Pearson correlation analysis showed that BNP was positively correlated with high sensitive C-reactive protein (hs-CRP,r=0.62,P<0.01) and CD62P(r=0.23,P<0.05),and negatively correlated with left ventricular ejection fraction (LVEF,r=-0.42,P<0.01); CD62P was positively correlated with hs-CRP(r=0.33,P<0.05)and not correlated with LVEF(r=0.13,P>0.05). (4) Multivariate regression analysis revealed that both hs-CRP and LVEF were independently correlated with BNP (β=0.609 and -0.412,respectively,P<0.01). Conclusion (1) BNP and CD62P are involved in the development of CHD; CD62P may reflect the coronary artery inflammation; they are correlated with the instability of plaque; they have significance in guiding diagnosis,treatment and risk stratification of CHD. (2) The plasma level of BNP is independently correlated with CRP and left ventricular systolic function respectively.