Objective To evaluate the therapeutic effects of polyethylene glycol electrolyte powder combined with mosapride on chronic functional constipation.Methods Eighty-six patients with chronic functional constipation were randomly divided into 3 groups:mosapride plus polyethylene glycol electrolyte group (A),mosapride group (B),and polyethylene glycol electrolyte group (C).The treatment lasted for 4 weeks.Results After 4 weeks of treatment,the total effectiveness rates were 96.9%,39.2% and 73.2% respectively in group A,B and C.The difference was significant between group A and the other 2 groups(P<0.01).Conclusion Combined use of polyethylene glycol electrolyte powder with mosapride can provide satisfactory therapeutic effects on patients with chronic functional constipation,which is clinically superior to single drug usage.