Objective To explore the risk factors of multiple cerebral infarctions(MCI) in aged patients in order to provide basis for its prevention and treatment. Methods Based on clinical observation, the correlative factors were identified in 1416 cases of cerebral infarction from January 2000 to January 2008. Then non-condition logistic regression analysis was employed to determine the risk factors of MCI. Results The main risk factors of MCI included atrial fibrillation, carotid artery plaque formation, diabetes and hypertension. They were independent risk factors of MCI. And there were significantl differences among these risk factors. Conclusion Atrial fibrillation, carotid artery plaque formation, diabetes and hypertension are the most important risk factors of MCI. Targeting to the specific risk factor, the individualized prevention and treatment strategy may be carried out in clinical practice,which has significant value in reducing the occurrence of MCI.