Objective To investigate the effect of the serum inflammatory factor on type 2 diabetes mellitus(T2DM) especially among elderly patients complicated with cardiocerebral vascular disease.Methods We studied 103 T2DM patients,and divided them into groups according to the age and whether complicated with cardiocerebral vascular disease or not.The levels of serum high sensitivity C-reactive protein(Hs-CRP),fasting blood glucose,glycosylated hemoglobin,cholesterol total,triglyceride(TG),and low density lipoprotein-cholesterol were detected with automatic biochemistry analyzer and serum tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) with ELISA in all patients.Results(1)Among them,the levels of serum Hs-CRP,TNF-α and IL-6 in patients of age≥65 years old were higher than those of age<65 years old(P=0.003,P=0.001,P=0.007,respectively).(2)The level of serum Hs-CRP in patients with T2DM complicated with cardiocerebral vascular disease was higher than those without it(P=0.015).And in patients of age≥65 years old,the level of serum Hs-CRP in patients complicated with cardiocerebral vascular disease was higher than that in the those without it(P=0.040).(3)The level of serum Hs-CRP was positively correlated with age and the level of serum TG(r=0.257,P=0.000;r=0.220,P=0.003).The impact factor on Hs-CRP was age,the regression equation was Y(Hs-CRP)=2.407+0.100X(age).(4)The incidence of cardiocerebral vascular disease in T2DM patients of age≥65 years old was higher than that in the patients of age<65 years old(P=0.000).Conclusion Inflammatory factors such as CRP,TNF-α and IL-6 are correlated with elderly T2DM patients complicated with cardiocerebral vascular disease;and age is a main impact factor on Hs-CRP.