【Abstract】Objective To explore the correlation of loneliness with social avoidance and quality of life in elderly patients with hemiplegia after hypertensive cerebral hemorrhage. Methods A retrospective analysis was conducted on 240 hemiplegia patients after hypertensive cerebral hemorrhage admitted to Department of Neurosurgery of our hospital from July 2020 to July 2023. According to the severity of hemiplegia, they were divided into mild group (n=84), moderate group (n=109) and severe group (n=47). Social avoidance scale, loneliness scale and World Health Organization Quality of Life Scale were used to evaluate their social avoidance, loneliness and quality of life. SPSS statistics 20.0 was used for statistical analysis. Data comparison between two groups was performed using LSD-t test, Wilcoxon test, χ2 test or F test depending on data type. Pearson correlation analysis was employed to analyze the correlation of loneliness with social avoidance and quality of life in the patients. Spearman analysis was applied to analyze the correlation of loneliness, social avoidance and quality of life with severity of the condition. Results Among the patients with different severities of hemiplegia after hypertensive cerebral hemorrhage, there were significant differences in social avoidance, social distress and total score (F=113.224,130.427,217.624; P<0.05), in the scores of interpersonal communication, subjective feeling, communication ability, self-cognition and total score (F=461.700,559.952,377.621,280.156,510.410; P<0.05), and in environmental, social, psychological and physiological scores and total score (F=163.106,113.470,72.978,80.031,101.783; P<0.05). Loneliness in the elderly hemiplegia patients was positively correlated with social avoidance and the severity of hemiplegia (r=0.669,0.873; P<0.05), and negatively with quality of life (r=-0.566; P<0.05). Social avoidance was negatively correlated with quality of life (r=-0.547; P<0.05), and positively with the severity of hemiplegia (r=0.810; P<0.05). The quality of life was negatively correlated with the severity of hemiplegia (r=-0.681; P<0.05). Conclusion In the elderly hemiplegia patients after hypertensive cerebral hemorrhage, loneliness is significantly correlated with social avoidance and quality of life. In clinical practice, besides treatment for the main symptoms, clinicians should actively pay attention to loneliness in these elderly patients and intervene it in time to improve their quality of life and social ability.