【Abstract】Objective To explore the correlation of nutritional status and self-efficacy with quality of life in elderly maintenance hemodialysis (MHD) patients with tuberculosis . Methods A retrospective analysis was made of the clinical data of 150 elderly MHD patients with tuberculosis admitted to Nanjing Hospital Affiliated to Nanjing University of Traditional Chinese Medicine from November 2020 to October 2023. The nutritional risk scale 2002 (NRS2002), general self-efficacy scale (GSES) and 36-item short form health survey (SF-36) were used to assess the nutritional risk, self-efficacy and quality of life scores of the patients, respectively. SPSS 26.0 was used for data analysis. According to the data type, t test or analysis of variance was used for comparison between groups. Pearson correlation analysis was used to evaluate the linear relationship between nutritional status and quality of life, and between self-efficacy and quality of life in elderly MHD patients with tuberculosis. Multivariate logistic regression model was used to analyze the factors influencing quality of life in elderly MHD patients with tuberculosis. Results The patients scored (4.85±1.39) points for NRS2002, (16.46±2.89) points for GSES, and (59.68±5.44) points for quality of life. Pearson correlation analysis showed that the score of NRS2002 was negatively correlated with the score of quality of life (r=-0.582; P<0.05) in elderly MHD patients with tuberculosis, and the score of self-efficacy was positively correlated with the score of quality of life (r=0.539; P<0.05). The multivariate logistic regression analysis showed that the average annual family income (OR=2.861,95%CI 1.507-5.430), treatment payment method (OR=3.093,95%CI 1.363-7.017), NRS2002 score (OR=0.378,95%CI 0.191-0.748) and GSES score (OR=3.013,95%CI 1.389-6.535) were the factors influencing quality of life in elderly MHD patients with tuberculosis (P<0.05). Conclusion The nutritional level and self-efficacy of elderly MHD patients with tuberculosis are factors that affect their quality of life. Assessing the nutritional status and self-efficacy of patients and providing relevant interventions are important for improving the quality of life of patients.