酮体氧化代谢在心血管疾病中的研究进展

doi:10.11915/j.issn.1671-5403.2025.02.030

首页 > 过刊浏览>2025年第24卷第2期 >148-152. DOI:10.11915/j.issn.1671-5403.2025.02.030

酮体氧化代谢在心血管疾病中的研究进展
DOI:
                        10.11915/j.issn.1671-5403.2025.02.030
                    
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                        尼鲁帕尔·谢甫开提1,2尼鲁帕尔·谢甫开提
新疆医科大学第一附属医院心血管内科,省部共建中亚高发病成因与防治国家重点实验室,乌鲁木齐 830054;新疆医学动物模型研究重点实验室,乌鲁木齐 830054
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阿曼古丽·如则1,2阿曼古丽·如则
新疆医科大学第一附属医院心血管内科,省部共建中亚高发病成因与防治国家重点实验室,乌鲁木齐 830054;新疆医学动物模型研究重点实验室,乌鲁木齐 830054
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夏依旦·米吉提1,2夏依旦·米吉提
新疆医科大学第一附属医院心血管内科,省部共建中亚高发病成因与防治国家重点实验室,乌鲁木齐 830054;新疆医学动物模型研究重点实验室,乌鲁木齐 830054
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赵帮豪1,2赵帮豪
新疆医科大学第一附属医院心血管内科,省部共建中亚高发病成因与防治国家重点实验室,乌鲁木齐 830054;新疆医学动物模型研究重点实验室,乌鲁木齐 830054
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高晓明1,2,3高晓明
新疆医科大学第一附属医院心血管内科,省部共建中亚高发病成因与防治国家重点实验室,乌鲁木齐 830054;新疆医学动物模型研究重点实验室,乌鲁木齐 830054;新疆医科大学临床医学研究院,乌鲁木齐 830054
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作者单位:(1.新疆医科大学第一附属医院心血管内科,省部共建中亚高发病成因与防治国家重点实验室,乌鲁木齐 830054;2.新疆医学动物模型研究重点实验室,乌鲁木齐 830054;3.新疆医科大学临床医学研究院,乌鲁木齐 830054)
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Research progress on ketone oxidative metabolism in cardiovascular diseases

Author:

Nilupaer·Xiefukaiti ^{^1,2}
Nilupaer·Xiefukaiti
Department of Cardiology, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia Co-Founded by Province and Ministry, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China;Xinjiang Key Laboratory of Medical Animal Model Research, Urumqi 830054, China
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Amanguli·Ruze ^{^1,2}
Amanguli·Ruze
Department of Cardiology, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia Co-Founded by Province and Ministry, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China;Xinjiang Key Laboratory of Medical Animal Model Research, Urumqi 830054, China
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Xiayidan·Mijiti ^{^1,2}
Xiayidan·Mijiti
Department of Cardiology, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia Co-Founded by Province and Ministry, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China;Xinjiang Key Laboratory of Medical Animal Model Research, Urumqi 830054, China
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Zhao Banghao ^{^1,2}
Zhao Banghao
Department of Cardiology, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia Co-Founded by Province and Ministry, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China;Xinjiang Key Laboratory of Medical Animal Model Research, Urumqi 830054, China
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Gao Xiaoming ^{^1,2,3}
Gao Xiaoming
Department of Cardiology, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia Co-Founded by Province and Ministry, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China;Xinjiang Key Laboratory of Medical Animal Model Research, Urumqi 830054, China;Clinical Medical Research Institute, Xinjiang Medical University, Urumqi 830054, China
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Affiliation:

(1.Department of Cardiology, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia Co-Founded by Province and Ministry, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China;2.Xinjiang Key Laboratory of Medical Animal Model Research, Urumqi 830054, China;3.Clinical Medical Research Institute, Xinjiang Medical University, Urumqi 830054, China)

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【摘要】心血管疾病是全球主要的死亡原因,具有发病率高、死亡率高、致残率高、复发率高等特点。生理状态下的心脏主要依靠脂肪酸和葡萄糖的氧化代谢来提供能量,然而,在心肌梗死、心力衰竭等各种病理状态下,心肌细胞内的脂肪酸和葡萄糖的代谢路径出现障碍,酮体作为“超级燃料”为心脏供能。本文根据最新报道,对酮体代谢在心血管疾病中的作用及机制进行综述。

关键词:心肌缺血;心肌肥厚;β-羟丁酸;β-羟丁酸脱氢酶

基金项目:国家自然科学基金(82060073,81870272)；新疆医科大学青年科技拔尖人才培养项目( XYD2024Q03) ；新疆重点实验室开放课题项目(2020D04027,2021D04020)

【Abstract】Cardiovascular disease is a leading cause of death worldwide, characterized by high morbidity, high mortality, high disability rate, and high recurrence rates. In physiological condition, the heart primarily relies on the oxidative metabolism of fatty acids and glucose to generate energy. However, in various pathological conditions, such as myocardial infarction and heart failure, the metabolic pathways for fatty acids and glucose in cardiomyocytes become impaired. In these situations, ketone bodies emerge as an alternative ‘super-fuel’ for the heart′s energy supply. In this article, we reviewed the role and mechanism of ketone body metabolism in cardiovascular diseases based on the latest reports.

Key words:myocardial ischemia; myocardial hypertrophy; β-hydroxybutyrate; β-hydroxybutyrate dehydrogenase

This work was supported by the National Natural Science Foundation of China (82060073, 81870272), Youth Science and Technology Elite Talent Program of Xinjiang Medical University ( XYD2024Q03 ) and the Open Topic Project of Xinjiang Key Laboratory (2020D04027, 2021D04020).

引用本文

尼鲁帕尔·谢甫开提,阿曼古丽·如则,夏依旦·米吉提,赵帮豪,高晓明.酮体氧化代谢在心血管疾病中的研究进展[J].中华老年多器官疾病杂志,2025,24(2):148-152

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收稿日期:2024-04-10
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在线发布日期: 2025-02-17
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