【Abstract】Objective To investigate the effects of radiofrequency target ablation combined with ozone injection on pain and functional rehabilitation of patients with lumbar disc herniation. Methods A retrospective analysis was made of the clinical data of 103 patients with lumbar disc herniation admitted to Nanchong Central Hospital from March 2021 to March 2023. According to treatment methods, the patients were divided into the control group receiving radiofrequency target ablation (n=51) and the study group receiving radiofrequency target ablation combined with ozone injection (n=52). After 6 months, the therapeutic effect, pain score before and after treatment and lumbar function score of the two groups were evaluated. SPSS statistics 20.0 was used for data analysis. According to the data type, t test orχ² test was used for data comparison between two groups. Results After treatment, the visual analogue score of study group was lower than that of control group [(3.27±0.84) vs (5.31±1.32) points], and the Oswestry disability index of study group was lower than that of control group [(15.26±2.64)% vs (19.32±3.57)%]. The low back pain score of Japanese Orthopaedic Society in study group was higher than that of control group [23.81±3.52) vs (20.37±2.81) points], and the total effective rate in the study group was higher than that of control group (92.31% vs 78.43%). The differences were statistically significant (P<0.05). Conclusion Radiofrequency target ablation combined with ozone injection can significantly reduce pain and promote functional recovery in the patients with lumbar disc herniation.