【Abstract】Objective To investigate the quality of life (QOL) in elderly patients with cervical radiculopathy and analyze its influencing factors. Methods A total of 163 elderly outpatients with cervical radiculopathy treated in our department from May 2020 to May 2023 were enrolled in this study. Chinese version of 36-Item Short Form Health Survey (SF-36) was used to investigate the QOL of the patients. SPSS statistics 20.0 was employed for data analysis. Depending on data type, student′s t test and analysis of variance were applied for intergroup comparison, and multiple linear regression analysis was conducted to analyze the factors affecting the QOL of elderly patients with radiculotic cervical spondylosis. Results The total score of QOL was(60.33±11.79)points in the 163 elderly patients with cervical radiculopathy. Univariate analysis showed that significant differences were observed in gender, time of sitting at a desk or with lowering head, education level, source of medical expense, course of disease, number of lesion segments, and Babinski reflex (P<0.05). Multiple linear regression analysis indicated that gender, time of sitting at a desk or with lowering head, education level, and course of disease were influencing factors for QOL in the elderly patients with cervical radiculopathy (t=4.693,2.513,3.022,4.663; P<0.05). Conclusion Elderly patients with cervical spondylotic radiculopathy have poor QOL. Gender, prolonged time of sitting at a desk or with lowering head, education level and course of disease are factors affecting their QOL. So, special attention should be paid to the patients with above factors in order to improve their QOL.