+高级检索
首页 > 过刊浏览>2022年第21卷第5期 >379-384. DOI:10.11915/j.issn.1671-5403.2022.05.082
PDF HTML阅读 XML下载 导出引用 引用提醒
环状RNA在心血管疾病发病机制中的研究进展
作者:
作者单位:

(1.山西医科大学第二临床医学院,太原 030001;2. 山西医科大学第二医院心血管内科,太原 030001)


Research progress on pathogenesis of circular RNA in cardiovascular diseases
Author:
Affiliation:

(1. Second Clinical Medical College of Shanxi Medical University, Taiyuan 030001, China;2. Department of Cardiology, Second Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China)

  • 摘要
    • | |
  • 访问统计
    • |
  • 参考文献 [38]
    • |
  • 相似文献 [20]
    • | | |
  • 文章评论

    【摘要】环状RNA(circRNA)是通过将RNA的3′末端连接到5′末端而环化,形成没有聚腺苷酸尾巴的共价闭环结构,具有广泛的分布性,在不同物种及亚细胞间均能发现。目前发现circRNA与心血管疾病、神经系统疾病、癌症等多种疾病的发生与发展密切相关,其作用机制包括充当miRNA海绵、与RNA结合蛋白相互作用、调控基因表达及编码蛋白质。本文从circRNA的生物发生和功能、circRNA在心血管疾病中的研究进展等方面进行综述。

    基金项目:山西省应用基础研究项目(201801D121321)

    【Abstract】Circular RNAs (circRNAs) are a novel class of RNA, cyclized by linking the 3′ end of the RNA to the 5′ end to form a covalently closed ring structure without a polyadenylic acid tail. CircRNAs are widely distributed, and can be found in various species and in different subcellular compartments. It has been found that circRNAs are closely related to the occurrence and development of cardiovascular diseases, neurological diseases, cancer and other diseases. Its mechanisms of action include acting as miRNA sponges, interacting with RNA-binding proteins, regulating gene expression, and encoding proteins. This article reviews the biogenesis and functions of circRNAs, and research progress in cardiovascular diseases.

    This work was supported by the Applied Basic Research Project of Shanxi Province (201801D121321).

    参考文献
    [1] 赵郑波.环状RNA circRNA-CER通过调控miR136/MMP13轴减轻氧化低密度脂蛋白诱导的内皮细胞损伤[D].重庆:重庆医科大学, 2020:74-75.DOI:10.27674/d.cnki.gcyku.2020.000252.Zhao ZB.Circular RNA circRNA-CER attenuates oxidized low-density lipoprotein-induced endothelial cell injury by regulating the miR136/MMP13 axis[D].Chongqing:Chongqing Medical University, 2020:74-75.DOI:10.27674/d.cnki.gcyku.2020.000252.
    [2] Geng HH, Li R, Su YM, et al.The circular RNA Cdr1as promotes myocardial infarction by mediating the regulation of miR-7a on its target genes expression[J].PLoS One, 2016,11(3):e0151753.DOI:10.1371/journal.pone.0151753.
    [3] Cao Q, Guo Z, Du S, et al.Circular RNAs in the pathogenesis of atherosclerosis[J].Life Sci, 2020,255:117837.DOI:10.1016/j.lfs.2020.117837.
    [4] Zhang Y, Chen B.Silencing circ_0062389 alleviates cardiomyocyte apoptosis in heart failure rats via modulating TGF-β1/Smad3 signaling pathway[J].Gene, 2021,766:145154.DOI:10.1016/j.gene.2020.145154.
    [5] Li B, Li Y, Hu L, et al.Role of circular RNAs in the pathogenesis of cardiovascular disease[J].J Cardiovasc Transl Res,2020,13(4):572-583.DOI:10.1007/s12265-019-09912-2.
    [6] Wang K, Gan TY, Li N, et al.Circular RNA mediates cardiomyocyte death via miRNA-dependent upregulation of MTP18 expression[J].Cell Death Differ,2017,24(6):1111-1120.DOI:10.1038/cdd.2017.61.
    [7] Vausort M, Salgado-Somoza A, Zhang L, et al.Myocardial infarction-associated circular RNA predicting left ventricular dysfunction[J].J Am Coll Cardiol, 2016,68(11):1247-1248.DOI:10.1016/j.jacc.2016.06.040.
    [8] Zhou LY, Zhai M, Huang Y, et al.The circular RNA ACR atte-nuates myocardial ischemia/reperfusion injury by suppressing autophagy via modulation of the Pink1/ FAM65B pathway[J].Cell Death Differ,2019,26(7):1299-1315.DOI:10.1038/s41418-018-0206-4.
    [9] 别自东, 郭富英, 穆彬, 等.circ_SEC23A通过miR-30a/Beclin-1通路促进AngⅡ诱导的心肌细胞损伤[J].北医学院学报, 2020,35(6):957-960,976.Bie ZD, Guo FY, Mu B, et al.circ_SEC23A promotes the injury of AngⅡ-induced cardiomyocytes through miR-30 a/Beclin-1[J].J North Med Coll,2020,35(6):957-960,976.
    [10] Cai L, Qi B, Wu X, et al.Circular RNA Ttc3 regulates cardiac function after myocardial infarction by sponging miR-15b[J].J Mol Cell Cardiol, 2019,130:10-22.DOI:10.1016/j.yjmcc.2019.03.007.
    [11] Huang S, Li X, Zheng H, et al.Loss of super-enhancer-regulated circRNA Nfix induces cardiac regeneration after myocardial infarction in adult mice[J].Circulation, 2019,139(25):2857-2876.DOI:10.1161/CIRCULATIONAHA.118.038361.
    [12] Garikipati VNS, Verma SK, Cheng Z, et al.Author correction:circular RNA circFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis[J].Nat Commun,2020,11(1):2234.DOI:10.1038/s41467-020-15382-x.
    [13] Li CY, Ma L, Yu B.Circular RNA hsa_circ_0003575 regulates oxLDL induced vascular endothelial cells proliferation and angiogenesis[J].Biomed Pharmacother,2017,95:1514-1519.DOI:10.1016/j.biopha.2017.09.064.
    [14] Boeckel JN, Jaé N, Heumüller AW, et al.Identification and chara-cterization of hypoxia-regulated endothelial circular RNA[J].Circ Res,2015,117(10):884-890.DOI:10.1161/CIRCRESAHA.115.306319.
    [15] Dang RY, Liu FL, Li Y.Circular RNA hsa_circ_0010729 regulates vascular endothelial cell proliferation and apoptosis by targeting the miR-186/HIF-1α axis[J].Biochem Biophys Res Commun, 2017,490(2):104-110.DOI:10.1016/j.bbrc.2017.05.164.
    [16] Ding P, Ding Y, Tian Y, et al.Circular RNA circ_0010283 regulates the viability and migration of oxidized low-density lipoprotein-induced vascular smooth muscle cells via an miR-370-3p/HMGB1 axis in atherosclerosis[J].Int J Mol Med,2020,46(4):1399-1408.DOI:10.3892/ijmm.2020.4703.
    [17] Hall IF, Climent M, Quintavalle M, et al.Circ_Lrp6, a circular RNA enriched in vascular smooth muscle cells, acts as a sponge regulating miRNA-145 function[J].Circ Res, 2019,124(4):498-510.DOI:10.1161/CIRCRESAHA.118.314240.
    [18] 代佩, 高奋, 高宏伟, 等.miRNA-33对Hcy干预RAW264.7巨噬细胞衍生的泡沫细胞表达ABCA1/ABCG1的影响[J].中国病理生理杂志, 2019,35(2):212-217.DOI:10.3969/j.issn.1000-4718.2019.02.004.Dai P, Gao F, Gao HW, et al.Effect of miRNA-33 on ABCA1/ABCG1 expression in RAW264.7 macrophage-derived foam cells after Hcy treatment[J].Chin J Pathophysiol, 2019,35(2):212-217.DOI:10.3969/j.issn.1000-4718.2019.02.004.
    [19] 温雯, 张建勋, 高奋.环状RNA调节脂质代谢在动脉粥样硬化中的作用[J].中国动脉硬化杂志, 2021,29(3):217-221.DOI:10.3969/j.issn.1007-3949.2021.03.005.Wen W, Zhang JX, Gao F.The role of circular RNA in regulating lipid metabolism in atherosclerosis[J].Chin J Arteriosclerosis, 2021,29(3):217-221.DOI:10.3969/j.issn.1007-3949.2021.03.005.
    [20] Zhou B, Yu JW.A novel identified circular RNA, circRNA_010567, promotes myocardial fibrosis via suppressing miR-141 by targeting TGF-β1[J].Biochem Biophys Res Commun, 2017, 487(4): 769-775.DOI:10.1016/j.bbrc.2017.04.044.
    [21] Tang CM, Zhang M, Huang L, et al.CircRNA_000203 enhances the expression of fibrosis-associated genes by derepressing targets of miR-26b-5p, Col1a2 and CTGF, in cardiac fibroblasts[J].Sci Rep, 2017,7:40342.DOI:10.1038/srep40342.
    [22] Liu W, Wang Y, Qiu Z, et al.CircHIPK3 regulates cardiac fibroblast proliferation, migration and phenotypic switching through the miR-152-3p/TGF-β2 axis under hypoxia[J].PeerJ Comput Sci, 2020,8:e9796.DOI:10.7717/peerj.9796.
    [23] 温艺红, 杨真祯, 张铭, 等.CircRNA_100395通过结合miR-144-3p抑制心肌成纤维细胞中纤维化相关基因的表达[J].中山大学学报(医学科学版), 2020,41(6):875-883.DOI:10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2020.0115.Wen YH,Yang ZZ,Zhang M, et al.CircRNA_100395 inhibits expression of myocardial fibrosis-related genes in human atrial myofibroblasts via sponging miR-144-3p[J].J Sun Yat-sen Univ(Med Sci Ed),2020,41(6):875-883.DOI:10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2020.0115.
    [24] Zhu Y, Pan W, Yang T, et al.Upregulation of circular RNA circNFIB attenuates cardiac fibrosis by sponging miR-433[J].Front Genet,2019,10:564.DOI:10.3389/fgene.2019.00564.
    [25] Du WW, Yang W, Chen Y, et al.Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses[J].Eur Heart J, 2017,38(18):1402-1412.DOI:10.1093/eurheartj/ehw001.
    [26] Zhang N, Wang X.Circular RNA ITCH mediates H2O2-induced myocardial cell apoptosis by targeting miR-17-5p via wnt/β-catenin signalling pathway[J].J Int J Exp Pathol, 2020,102(1):22-31.DOI:10.1111/iep.12367.
    [27] Khan MA, Reckman YJ, Aufiero S, et al.RBM20 regulates circular RNA production from the titin gene[J].Circ Res, 2016,119(9):996-1003.DOI:10.1161/circresaha.116.309568.
    [28] Siede D, Rapti K, Gorska AA, et al.Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease[J].J Mol Cell Cardiol, 2017,109:48-56.DOI:10.1016/j.yjmcc.2017.06.015.
    [29] Zeng Y, Du WW, Wu Y, et al.A circular RNA binds to and activates AKT phosphorylation and nuclear localization reducing apoptosis and enhancing cardiac repair[J].Theranostics, 2017,7(16):3842-3855.DOI:10.7150/thno.19764.
    [30] Wang X, Cheng Z, Xu J, et al.Circular RNA Arhgap12 modulates doxorubicin-induced cardiotoxicity by sponging miR-135a-5p[J].Life Sci, 2021,265:118788.DOI:10.1016/j.lfs.2020.118788.
    [31] Wang K, Long B, Liu F, et al.A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223[J].Eur Heart J,2016,37(33):2602-2611.DOI:10.1093/eurheartj/ehv713.
    [32] Li H, Xu JD, Fang XH, et al.Circular RNA circRNA_000203 aggravates cardiac hypertrophy via suppressing miR-26b-5p and miR-140-3p binding to Gata4[J].Cardiovasc Res, 2020,116(7):1323-1334.DOI:10.1093/cvr/cvz215.
    [33] Jiang S, Guo C, Zhang W, et al.The integrative regulatory network of circRNA, microRNA, and mRNA in atrial fibrillation[J].Front Genet,2019,10:526.DOI:10.3389/fgene.2019.00526.
    [34] Zhang PP, Sun J, Li W.Genome-wide profiling reveals atrial fibrillation-related circular RNAs in atrial appendages[J].Gene, 2020,728:144286.DOI:10.1016/j.gene.2019.144286.
    [35] Hu M, Wei X, Li M, et al.Circular RNA expression profile of persistant atrial fibrillation in patients with rheumatic heart disease[J].Anatol J Cardiol, 2019,21(2):2-10.DOI:10.14744/AnatolJCardiol.2018.35902.
    [36] Bao X, Zheng S, Mao S, et al.A potential risk factor of essential hypertension in case-control study:circular RNA hsa_circ_0037911[J].Biochem Biophys Res Commun,2018,498(4):789-794.DOI:10.1016/j.bbrc.2018.03.059.
    [37] He X, Bao X, Tao Z, et al.The microarray identification circular RNA hsa_circ_0105015 up-regulated involving inflammation pathway in essential hypertension[J].J Clin Lab Anal, 2020, 35(2):23603.DOI:10.1002/jcla.23603.
    [38] 刘婉月, 孙义, 黄淑娜, 等.环状RNA hsa_circ_0001946和hsa_circ_0125589及环境因素与高血压的关联[J].中华高血压杂志,2020,28(1):53-58.DOI:10.16439/j.cnki.1673-7245.2020.01.017.Liu WY, Sun Y, Huang SN, et al.Correlation of circular RNAs hsa_circ_0001946 and hsa_circ_0125589 and environmental factors with hypertension[J].Chin J Hypertens, 2020,28(1):53-58.DOI:10.16439/j.cnki.1673-7245.2020.01.017.
    引证文献
    网友评论
    网友评论
    分享到微博
    发 布
引用本文

薛拴勤,朱洁,陈丽君,高奋.环状RNA在心血管疾病发病机制中的研究进展[J].中华老年多器官疾病杂志,2022,21(5):379-384

复制
分享
文章指标
  • 点击次数:282
  • 下载次数: 260
  • HTML阅读次数: 0
  • 引用次数: 0
历史
  • 收稿日期:2021-02-20
  • 在线发布日期: 2022-05-30
文章二维码
您是第4225817 位访问者
主管单位：中国人民解放军总医院
主办单位：解放军总医院医学创新研究部、国家老年疾病临床医学研究中心（解放军总医院）、解放军总医院第六医学中心心血管病医学部
地址：北京市复兴路28号《中华老年多器官疾病杂志》编辑部
电话：010-66936756
中华老年多器官疾病杂志 ® 2025 版权所有 技术支持：北京勤云科技发展有限公司