Heat stroke is a clinical syndrome with an imbalance of heat production and heat dissipation due to exposure to a thermal environment and/or intense exercise, characterized by increasing core body temperature ＞40 ℃ and central nervous system abnormalities(such as delirium, convulsion, coma), accompanied by a life-threatening clinical syndrome of multiple organ damage. According to the different causes and susceptible populations, heat stroke is categorized into classic heat stoke and exertional heat stroke. Heat stroke can cause changes in function and morphology of multiple organs, resulting in multiple organ dysfunction syndrome, which is the leading cause of patient′s death. Currently, no treatment is proven effective other than symptomatic treatment. Understanding the multiple organ injury features caused by heat stroke has a profound significance for its clinical treatment and mortality decrease.