Objective To explore the association of serum uric acid (UA) with local muscle mass in the elderly males in a view to providing a new perspective and basis for the prevention and control of sarcopenia. Methods A total of 350 males aged 60 years and over in the Department of Geriatrics in Affiliated Hospital of Nanjing University Medical School from January 2019 to December 2021 were selected as subjects. According to serum UA, they were divided into four groups:Q1 (0-<320 μmol/L), Q2 (320-<360 μmol/L), Q3 (360-<420 μmol/L), and Q4 (≥420 μmol/L) (Q=quadrant). The four groups were compared in the muscle percentiles of the hip and spine, and blood lipids. SPSS statistics 20.0 was used for data analysis. According to data type, comparison between groups was performed using Nonparametric Kruskal-Wallis H test. After adjusting for age, body mass index, blood lipid and other confounding factors, partial correlation was used to analyze the correlation between serum UA and local muscle mass. Results With higher UA, total cholesterol, triglyceride, serum creatinine increased significantly in Q4 group (P<0.05). There was no significant difference in the hip muscle mass between the four groups (P=0.641), and serum UA levels showed a reverse J-shaped curve with hip muscle mass. Pinal muscle mass in the Q4 group was significantly lower than that in the Q1 group (P=0.024). There was a significant negative correlation between UA level and the hip muscle mass in the Q4 group (r=-0.239, P=0.006), but no correlation was found between UA and the waist muscle mass in the same group. Conclusion Hyperuricemia can cause a decrease in local muscle mass, especially of the hip, in the males aged 60 years or over. It is advised to keep serum UA at an optimal level (UA<420 μmol/L) to help maintain skeletal muscle mass and hip muscle percentile.