As China is entering the aging society, the impact of psychological problems of the elderly on health has attracted increasing social attention. In the elderly population, fluctuations of blood pressure can lead to diseases such as sudden cardiac death and myocardial infarction, and negative emotions such as anxiety and depression are independent risk factors of blood pressure fluctuations in patients. Orthostatic blood pressure changes coexisting with anxiety-depression result in more complicated condition and worse prognosis in the elderly. However, the correlation between the two and their main mechanisms are not yet fully understood with a dearth of relevant studies, warranting further research and elucidation of the role that potential modifiable factors play in the development of such a complex condition. This article reviews the correlation and possible mechanisms between orthostatic blood pressure changes and anxiety-depressive events in the elderly, providing research directions for the diagnosis and treatment of orthostatic blood pressure changes and anxiety-depression in the elderly.