Heart diseases are among the common diseases that cause disabilities and deaths in humans. Heart sounds refer to those produced due to the vibrations caused by the valve opening or closure, the blood rushing through the valve openings, or the blood rushing through the aortic wall of the ventricle. Heart sounds are obviously related to the heart structure and function. As a non-invasive auxiliary diagnostic tool, heart sound detection technology plays an important role in the diagnosis and treatment of cardiovascular diseases. Therefore, heart sound monitoring technology has gradually gained attention from scholars at home and abroad, and there have been more and more studies on its clinical application in recent years. This article reviews the relevant literature on the clinical application of heart sound monitoring technology and prospects its application in the emerging mobile health care and perioperative monitoring.