Objective To investigate the related factors influencing restenosis after common femoral artery endarterectomy (CFAE) in treatment of arteriosclerosis obliterans at common femoral artery (CFA). Methods A total of 136 patients with arteriosclerosis obliterans at CFA who underwent CFAE in our hospital from January 2011 to September 2019 were retrospectively subjected in this study. The patients with restenosis of common femoral artery > 70% were included in the restenosis group (n=47), and those of restenosis≤ 70% in the patency group (n=89). The clinical data were compared between the 2 groups. Cox proportional hazards regression model was used to analyze the influencing factor for restenosis after endarterectomy. SPSS statistics 21.0 was used for statistical analysis. Data comparison between 2 groups was performed using student′s t test or Chi-square test depending on data type. Results Forty-seven of 136 patients (34.6%) suffered from restenosis. There were significant differences in proportions of diabetes and smoking history and level of low-density lipoprotein cholesterol between the patency group and the restenosis group [30 (63.8%) vs 35 (39.3%), 29 (61.7%) vs 29 (32.6%), (1.79±0.58) vs (1.54±0.46) mmol/L, all P<0.05]. Obvious difference was seen in the situation of below-the-knee run-offs between the 2 groups (P<0.05). In both groups, 1 case of inguinal hematoma occurred in 1 d after operation and 1 case of local lymphatic leakage occurred in 3 d after operation. All patients were cured after symptomatic treatment. Results of Cox proportional hazard model showed that diabetes mellitus (RR=2.339,95%CI 1.273-4.296, P=0.006), smoking history (RR=1.931, 95%CI 1.063-3.507, P=0.031) and below-the-knee run-offs (RR=0.412,95%CI 0.217-0.783, P=0.007) were independently related with restenosis after CFAE. Conclusion Comorbidity of diabetes mellitus and smoking history are independent risk factors of restenosis in patients after CFAE. Initiative management of below-the-knee run-offs may reduce the incidence of restenosis.