Hypertension, a common disease with a high incidence in the world, is a major risk factor for many cardiovascular and cerebrovascular diseases, which brings a huge economic burden to society. In recent years, the incidence of anxiety and depressive disorders has increased, and the number of hypertensive patients with comorbid anxiety and/or depression is also increasing. Studies have shown that they may mutually reinforce each other and have some commonalities in the pathogenesis. However, the mechanism of comorbidities has not been fully elucidated. Therefore, this article reviews the definition and diagnostic scale, epidemiology, interaction mechanism and treatment of primary hypertension with anxiety and/or depression to provide guidance for clinical practice.