Objective To evaluate the predictive value of serum uric acid level for vascular dementia. Methods A total of 47 patients with vascular dementia treated in our health service center from June 2020 to May 2021 were enrolled in this retrospective study and assigned into the observation group, and another 46 healthy volunteers subjected during the same period served as control group. The severity of dementia was assessed with the clinical dementia rating (CDR) scale. SPSS statistics 24.0 was used to perform the statistical analysis. Student′s t test or Chi-square test was employed for intergroup comparison depending on different data types. Binary logistic regression analysis was adopted to analyze the risk factors of vascular dementia, and Spearman correlation analysis was performed to analyze the correlation of serum uric acid level and CDR score. Receiver operating characteristic (ROC) curve was drawn to assess the predictive value of the serum uric acid level for vascular dementia. Results The serum uric acid level was significantly higher in the observation group than the control group [(314.03±118.49) vs (228.20±65.24)mmol/L; P<0.01]. Serum uric acid level was positively correlated with CDR score (r=0.797, P<0.01). Serum uric acid level (OR=1.025, P=0.000,95%CI 1.014-1.036) and carotid intima media thickness (OR=0.055, P=0.003,95%CI 0.008-0.369) were risk factors for vascular dementia. ROC curve analysis revealed that the serum uric acid level (cut-off value=284.52 mmol/L, sensitivity=53.29%, specificity=91.31%) was a predictor of vascular dementia with an area under the curve of 0.768. Conclusion Serum uric acid level can be used as a predicative indicator for vascular dementia, and is positively correlated with its severity.