Objective To investigate the therapeutic effect of medium-frequency electrical stimulation and leg cycle ergometer training (LCETT) for sarcopenia patients. Methods Included in the study were 94 sarcopenia patients in the Department of Geriatrics of Yibin Municipal Second People′s Hospital from September 2017 to February 2020, who were divided into study group (n=46) and control group (n=48). The study group was treated with medium-frequency electrical stimulation and LCETT and the control group without. The two groups were evaluated 4 weeks later for the change in grip strength, Berg Balance Scale (BBS) , modified rivermead mobility index (MRMI), short physical performance battery (SPPB), senile disability score, percentage of neutrophils [NEUT (%)], C-reactive protein (CRP) and high-sensitivity C-reactive protein (hs-CRP). SPSS 23.0 was used for statistical analysis. Data comparison between two groups was performed using t-test or χ²test depending on data type. Results After 4-week treatment, no statistical difference was found in grip strength in the study group [(12.72±1.59) vs (10.03±1.38) kg, P>0.05], and significant differences were found in BBS score [(24.76±4.16) vs (17.38±2.90) points], SPPB score [(4.13±0.72) vs (2.15±0.48) points; P<0.05 for both]. MRMI and senile disability scores were statistically different in the study group before and after treatment and between two groups after the treatment [(27.57±2.74) vs (20.37±2.10) vs (20.58±1.47) points, (117.62±12.57) vs (93.39±8.74) vs (102.26±13.67) points; P<0.05 for all]. After 4-week treatment, the percentage of neutrophils had no significant change [(60.29±3.55)% vs (64.30±4.03)%, P>0.05)]; CRP had significant change[(13.56±0.90) vs (16.29±2.07) mg/L, P<0.05]; and hs-CRP were significantly different as compared with that before treatment and of the control group [(4.06±0.94) vs (5.31±0.87) vs (5.42±0.73) mg/L, P<0.05]. Conclusion Medium-frequency electrical stimulation combined with LCETT can improve the mobility, equilibrium, performance status, and inflammatory state in the sarcopenia patients, bringing clinical benefits for sarcopenia patients by strengthening the muscles and enhancing muscular functions.