Calcification of heart valves is a chronic, degenerative change, and its incidence gradually increases with age. With the development of CT and ultrasound technology, the detection rate of the condition has been increasing. However, its clinical significance has not been fully understood. In recent years,calcification of heart valves has been found to be associated with various cardiovascular diseases such as coronary heart disease, arrhythmia and heart failure. This present paper reviews the latest progress in the relationship between the condition and various cardiovascular diseases in a view of providing new ideas for its diagnosis and treatment.