Abstract:Frailty, one of the most common geriatric syndromes, increases mortality, adverse cardiovascular events, and bleeding risk in elderly patients with acute coronary syndrome ( ACS). Patients with frailty receive percutaneous coronary intervention (PCI) less frequently than those without, and frailty increases mortality of patients with PCI. There is a lack of evidence whether frail elderly patients can benefit from PCI and evidence to guide clinical decisions.