Mitochondria constitute an important part of cell infrastructure. They are the main places for energy production and participants in such processes as cell differentiation, cell information transmission and cell apoptosis. Mitochondria in sepsis are damaged in many ways, including hypoxia, damaged respiratory chain, endocrine changes, mitochondrial permeability transition, calcium overload, and mitochondrial DNA damage. Recently, many researchers have studied the methods for mitochondrial repair in sepsis, hoping to find new treatment methods for sepsis patients. This article reviews the mechanism of mitochondrial damage and repair methods in sepsis, providing theoretical basis and research hotspots for the diagnosis and treatment of sepsis.