Objective To investigate the efficacy of batroxobin combined with hyperbaric oxygen in treatment of sudden sensorine hearing loss (SSHL) in the elderly and the influencing factors on the prognosis. Methods A total of 209 elderly SSHL patients admitted to our medical center from June 2017 to June 2019 were recruited, and randomly divided into control group (n=104) and study group (n=105). The former group was treated with batroxobin, and the latter was treated with hyperbaric oxygen besides batroxobin. The clinical efficacy and incidence of adverse reactions were compared between the two groups, and the prognostic factors were analyzed. SPSS statistics 19.0 was used to perform the statistical analysis. Student′s t test or Chi-square test was employed for comparison between the groups. Binary logistic regression analysis was applied to analyze the independent factors affecting the prognosis. Results After treatment, the total effective rate was 80.95% in the study group, significantly higher than that (68.26%) of the control group(P<0.05). The hemodynamic parameters and antioxidant enzyme activity were significantly improved in both groups (P<0.05), and the improvements were more obvious in the study group (P<0.05). There was no statistical difference in the incidence of adverse reactions between the study group and control group (37.14% vs 34.62%, P>0.05). Age, diabetes, side of affected ear, interval from symptom onset to medical consultation, incidence, sense of ear fullness, and type of hearing loss curve were influencing factor on the prognosis. The results of binary logistic regression analysis showed that the type of hearing loss curve and the time from symptom onset to consultation were independent prognostic factors. Conclusion Batroxobin combined with hyperbaric oxygen is effective and safe in the treatment of elderly SSHL, and the type of hearing loss curve and the time from onset to consultation can be used as independent prognostic factors to predict its treatment effect.