Age is an independent risk factor for frailty. Accelerated aging of the population results in an increasing number of frail people.The incidence of coronary heart disease increases with age, and about 11 million Chinese are suffering from the condition. Studies have found that frailty is closely related to the incidence and prognosis of coronary heart disease. This article mainly introduces the incidence of, assessment tools for, and risk factors for frailty, explores the mechanism of frailty and coronary artery disease and the progress in clinical research both at home and abroad with a view of providing basis for improving the prognosis of patients with frailty and coronary artery disease.