Abstract:Long non-coding RNA plays an important role in the occurrence and development of cancer. Taurine up-regulated gene 1 (TUG1) has different expression levels and possesses different mechanisms of action in different cancers, but its role in glioma still remains controversial. TUG1 can regulate transcription factors by epigenetic means, and also regulate the expression of post-transcriptional genes through competitive endogenous RNA. TUG1 regulates the occurrence and development of glioma, which probably be associated with tumor self-renewal, cell cycle, apoptosis, chromatin stability, blood tumor barrier and angiogenesis. This article reviews the mechanism of TUG1 in gliomas, summarizes the current research results of TUG1 in glioma, and predicts its clinical application.