Parkinson disease (PD), as the second most common neurodegenerative disease, its pathogenesis is still unclear. Both genetic and environmental factors play important roles in its incidence and development. The main pathological features of the disease are degeneration of substantia nigra and formation of Lewy bodies. As well known, statins are commonly used as cholesterol-lowering drugs, and can alleviate oxidative stress and neuroinflammatory damage in neurodegenerative diseases to some extents. In this review, we focus on the neuroprotective effect of statins in order to provide a reference for the future diagnosis and treatment of PD.