Objective To investigate the establishment and preliminary practice of home management mode for patients with lower extremity arteriosclerosis obliterans (ASO). Methods A total of 81 patients with lower extremity ASO were enrolled, who were admitted to Department of Vascular Surgery of Yibin First People′s Hospital from May 2016 to April 2018. According to management modes employed after discharge, they were divided into control group (n=40) and study group (n=41). The patients in the control group were followed up by telephone at 1 and 12 months after discharge. For the study group, the home-based management mode was adopted,i.e. supervision and guidance were provided concerning the patients′ compliance behaviors (medication, smoking cessation, diet, rehabilitation exercise, limb protection, family support, and regular reexamination) via telephone + Wechat at 1,2, 3,6, 9 and 12 months after discharge. The two groups were compared in the respects of recorded rate of compliance, recurrence and amputation, and improvement of ASO Fontaine stage. SPSS statistics 19.0 was used for analysis, and Chi square test for the comparison between two groups. Results On discharge, 10 patients in the study group were of Fontaine stage Ⅰ, 19 of stage Ⅱ, 10 of stage Ⅲ, and 2 of stage Ⅳ; and the numbers were 23,3, 5 and 0 in the same order of stages at 12 months after discharge. In control group, 9 were of Fontaine stage Ⅰ, 17 of stage Ⅱ, 12 of stage Ⅲ, and 2 of stage Ⅳ, and the numbers were 7,6, 13, and 4 in the same order of stages at 12 months after discharge. There was no significant difference in the proportion of Fontaine stages between the two groups at the time of discharge (P>0.05). At 12 months after discharge, there was significant difference between the two groups in the proportion of Fontaine staging (P<0.05). Compared with those on discharge, the ASO symptoms in the study group were significantly improved at 12 months after discharge (P<0.05), while those in control group were significantly worse. Compared with control group, the proportion of patients with good compliance behaviors in the study group increased significantly, and the proportion with recurrence and amputation decreased significantly at 12 months after discharge (P<0.05). Conclusion The implementation of home management for the patients with lower extremity ASO can enhance patient′s compliance, alleviate lower limb ischemia, and reduce recurrence rate and amputation rate.