Objective To explore the effect of pain nursing intervention on postoperative pain in the patients with lower extremity arteriosclerosis obliterans (ASO). Methods From May 2016 to January 2018,2 patients with ASO were enrolled in this study, who underwent surgical treatment in the Department of Vascular Surgery of the Shanghai Ninth People′s Hospital. They were divided into observation group and control group (46 patients each). Both groups received unilateral balloon dilatation and stenting in the lower extremity. The control group received routine nursing after operation, while the observation group received pain nursing intervention featuring pain assessment management, multi-facet assessment, individualized pain management, multimodal health education, and intraoperative intervention. The two groups were compared in postoperative pain scores (digital rating scale or WONG-BAKER facial expression scale), sleep time, anorexia, ambulation after operation, days of hospitalization, and satisfaction with nursing. SPSS statistics 19.0 was used for data analysis. Depending on the data type, t test or χ² test is employed for comparison between two groups. Results On admission, there was no significant difference in pain score between control group and observation group [(3.50±1.14) vs (3.50±1.10), P=1.000]. At discharge, the pain score of the observation group was significantly lower than that of control group [(1.28±0.41) vs (2.39±0.77), P<0.001], and the scores for both groups were significantly lower as compared with those at admission with a statistically significant difference (P<0.05). Compared with control group, the observation group had earlier ambulation after operation, shorter hospitalization, longer sleep time, and better nursing satisfaction, the difference being statistically significant. However, no significant difference was observed in appetite between two groups (P=0.086). Conclusion Pain nursing intervention can relieve pain to a greater degree, improve sleep quality in ASO patients after operation, and enhance patients′ satisfaction with nursing.