Objective To explore the effect of integrated cardiac rehabilitation model (center- and home-based cardiac rehabilitation) on cardiopulmonary function and psychological status in patients with myocardial infarction. Methods A total of 84 cases of acute myocardial infarction within 3 months and referred to the Cardiovascular Rehabilitation Center of Chinese General Hospital of PLA from July 2017 to March 2018 were enrolled, and then randomized into treatment group and control group, with 42 patients in each group. The patients of the treatment group were treated with center-based exercise followed by health education of 15 min by medical staffs, twice a week for totally 18 weeks, and then home-based exercise for another 6 weeks. While, those in the control group were given health education for only once. Body mass index, waist-to-hip ratio, indices of cardiopulmonary exercise testing, and scores of generalized anxiety disorder (GAD-7) and patient health auestionnaire (PHQ-9) were compared before and after treatment between the 2 groups. SPSS statistics 19.0 was used to perform the statistical analysis. Student′s t test or Chi-square test was employed for different data types. Results After 24 weeks of integrated cardiac rehabilitation, the patients of the treatment group obtained significantly lower waist-to-hip ratio [(0.91±0.64) vs (0.93±0.51)], GAD-7 score [(2.60±3.02) vs (4.69±4.61)], PHQ-9 score [(4.14±2.54) vs (6.26±3.51)], and minute ventilation/carbon dioxide production (VE/VCO₂) slope [(23.46±5.09) vs (25.31±4.00)], and obviously increased peak oxygen uptake per kilogram [Peak VO₂/kg, (23.43±5.88) vs (20.70±4.13)ml/(min·kg)], maximal metabolism equivalents [MET_max, (6.62±1.68) vs (5.92±1.18)], and oxygen pulse [(13.25±4.06) vs (11.78±3.48)ml/beat] (all P<0.05). What′s more, the Peak VO₂/kg [(23.43±5.88) vs (19.48±4.47)ml/(min·kg)], MET_max [(6.62±1.68) vs (5.66±1.25)], oxygen pulse [(13.25±4.06) vs (11.76±0.70)ml/beat] were notably higher, while the waist-to-hip ratio [(0.91±0.64) vs (0.94±0.44)] were obviously decreased in the treatment group than the control group (P<0.05). Conclusion Integrated cardiac rehabilitation can promote cardiopulmonary exercise function, improve mental disorders such as anxiety and depression, and is worthy of clinical promotion for myocardial infarction population.