Mitochondrial dysfunction and inflammation are signs of aging and chronic degenerative diseases. Mitochondrial dysfunction may be the initiating factor of aging in which process oxidative mitochondrial DNA damage occurs at varying degrees, resulting in impaired energy metabolism, cell dysfunction, and even death of cells. At the same time, the persistent low-level inflammatory response of aging organisms can impair the activation of the immune system through a variety of functions and the role of inflammatory metabolites in regulating immune response also can provide evidence for intervening the pathological process of age-related diseases.