Sarcopenia is a degenerative syndrome characterized by reduced skeletal muscle mass, strength and function. It is closely related to aging, but some diseases like chronic kidney disease can accelerate muscle wasting and increase the incidence of sarcopenia. Those patients suffering from chronic kidney disease are prone to sarcopenia, and its mechanisms include inflammatory responses, protein energy wasting, reduced exercise and vitamin D deficiency. Early identification and intervention for sarcopenia is essential for improving the quality of life in the patients with chronic kidney disease complicated with sarcopenia. At present, the intervention measures mainly include physical exercise, nutrition supplement and drug treatment. This paper reviews the recent research progress in the pathogenesis, mechanism and treatment of chronic kidney disease complicated with sarcopenia.