Objective To investigate the effect of different types of Helicobacter pylori (H.pylori) on lipid profiles and inflammatory factors in the elderly patients with coronary heart diseases (CHD). Methods A total of 142 elderly CHD patients admitted in our department from January 2016 to June 2018 were enrolled in this study. The patients underwent ¹⁴C-urea breath test and H.pylori antibody classification, and were then divided into 3 groups:type Ⅰ H.pylori infection group (n=41), type Ⅱ H.pylori infection group (n=33), and H.pylori negative group (n=68). The severity of coronary artery lesion was recorded at admission. Fasting venous blood samples were collected for the levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and IL-8. SPSS statistics 23.0 was used to analyze the data. According to the data types, One-way ANOVA, LSD test, Chi-square test, or linear trend test was used for intergroup comparison. Results There were significant diffe-rences in the levels of hs-CRP, IL-6, IL-8 and TNF-α among the 3 groups (P<0.05). Compared with H.pylori negative group, the type Ⅰand Ⅱ H.pylori infection groups had significantly higher TC and LDL-C level, while the former group also had obviously lower HDL-C (P<0.05). The LDL-C level was markedly higher while that of LDL-C were reduced in the type Ⅰ H.pylori infection group than the type Ⅱ H.pylori infection group (P<0.05). In H.pylori negative group, the proportions of single, 2 and 3 coronary artery lesions accounted for 66.2%(45 cases), 17.6%(12 cases) and 16.2%(11 cases), respectively. While the proportions above were 19.5%(8 cases), 36.6%(15 cases) and 43.9%(18 cases) in type Ⅰ H.pylori infection group, and 36.4%(12 cases), 30.3%(10 cases) and 33.3%(11 cases) in type Ⅱ H.pylori infection group. Linear trend test showed that there were significant differences in internal composition of the severity of coronary artery lesion among the 3 groups (χ²=20.79, P<0.001). Conclusion H.pylori infection, especially that of type I, is associated with increased levels of inflammatory factors and deterioration of dyslipidemia in elderly CHD patients.