Objective To explore the influencing factors for greater tricuspid regurgitation after the implantation of cardiovascular implantable electronic devices (CIEDs), and investigate its possible mechanism. Methods Clinical data of 198 patients who undergoing implantation of CIEDs (including single- or dual-chamber permanent pacemakers, embedded cardioverter-defibrillators and cardiac resynchronisation therapy) in our department from January 2014 to December 2016 were collected in this study. According to the changes of tricuspid regurgitation observed by echocardiography before and after implantation, the selected patients were divided into unaggravated tricuspid regurgitation group (n=146) and aggravated tricuspid regurgitation group (n=52). Clinical data and preoperative echocardiographic data were compared between the 2 groups. SPSS statistics 17.0 was used to perform the statistical analysis. Mann-Whitney U test, unpaired Chi-square test or Fisher exact probability test was employed for comparison between groups. Multivariate logistic stepwise regression was applied to analyze the risk factors for tricuspid regurgitation. Results Compared with the unaggravated group, the proportions of male, preoperative creatinine clearance rate, hyperlipidemia and implantation time >12 months were significantly higher, while the proportions of smaller preoperative right atrial diameter and mitral and tricuspid regurgitation were obvious lower in the aggravated group (P<0.05). Multiple logistic regression analysis showed that implantation time (OR=1.000,5%CI 1.001-1.003; P=0.013) and hyperlipidemia (OR=2.024,5%CI 6.728-22.360; P=0.022) were independent risk factors for aggravation of tricuspid regurgitation, and mild tricuspid regurgitation before CIED implantation ( OR=0.018,5%CI 0.049-0.133; P<0.001) was independent protective factor for the aggravation. Conclusion CIED implantation time and hyperlipidemia can aggravate tricuspid regurgitation, and the severity of tricuspid regurgitation before operation is correlated with the aggravation after implantation. Attention should be paid to follow-up observation.