Objective To evaluate the efficacy of multidisciplinary medical intervention in the management of the elderly patients with acute-phase diseases and its effects on the prognosis. Methods Included as the study group were 122 elderly patients with acute-phase diseases and concomitant geriatric syndromes who received multidisciplinary medical intervention from September 2017 to March 2018, and as control group were 140 elderly patients with acute-phase diseases and concomitant geriatric syndromes treated from October 2016 to April 2017. The 2 groups were compared in the aspects of medications, patients′ satisfaction, hospitalization expenditure, Bathel activies of daily living (ADL) score on discharge, days of hospitalization, all-cause mortality and other outcome measures. SPSS statistics 22.0 was used for statistical analysis, and t test or Chi-square test for comparison between groups. Results Compared with control group, the applied drug species [(8.28±0.18) vs (9.33±0.22), P<0.05]and hospitalization length [(10.42±0.51) vs (11.21±0.73)d, P<0.05] decreased, patients′ satisfaction [(97.56±4.19) vs (91.22±3.71) score, P<0.05] increased, hospitalization expenditure [(7187.55±17.24) vs (7469.34±22.18) RMB￥, P<0.05] decreased, the Barthel ADL score [(83.36±4.29) vs (63.77±5.36), P<0.05] increased and all-cause mortality (1.64% vs 4.63%, P<0.05) decreased. Conclusion Multidisciplinary medical intervention in the elderly contributes to greater patient′s independence, shorter hospitalization and lower expenditure, the decreased mortality, and greater satisfaction of patients and their families.