Objective To assess the multimorbidity spectrum, multiple organ dysfunction, polypharmacy and expenditure among elderly inpatients from five clinical centers (Chinese PLA General Hospital, etc) over last 10 years,so as to provide technical guidance and objective evaluation for the study of prevention and treatment of multimorbidity. Methods Data were collected from elderly in-patients aged over 65 years form five clinical centers in China from January 2008 to December 2017. We further assessed multimorbidity spectrum, mortality, polypharmacy,expenditure among the elderly inpatients classified by gender and age over the decade.Results There were 370 996 inpatients enrolled in this study and the total number of hospitalizations reached 694 138. The average age of patients was 72.25 years. The number of elderly inpatients has increased significantly over the last decade, and the average annual growth rate was 27.48%. Malignant tumors(37.18%), hypertension(36.69%), ischemic heart disease(29.18%), diabetes mellitus (20.75%) and cerebrovascular diseases (13.19%) ranked top of the list.Ischemic heart disease with hypertension was the most prevalent comorbidity disease, and malignant tumors with hypertension increased with the annual rate of 42.99%.The proportion of taking more than 5 kinds of medications reached 43.88%. Conclusion (1) The problem of chronic diseases and comorbidity are prominent in the elderly with the ageing of the population. (2)We should strengthen multidisciplinary joint diagnosis and make reasonablemedication and treatment strategies for chronic diseases in the elderly, including ischemic heart disease, hypertension, malignant tumors, diabetes, etc. (3)Malignant tumor is the first cause of in-hospital death, therefore it′s important to facilitate early diagnosis and increase survival rate, and improve consistency of medical resources.