Objective To investigate the changes in medical expenditures in the patients with diabetic foot ulcers treated during 2006 to 2015. Methods The medical records of those first diagnosed as diabetic foot in Chinese PLA Hospital No.306 from 2006 to 2015 were retrieved from a self-developed database for the analysis of their medical expenditures. Results A total of 1962 patients (1201 males and 761 females) with diabetic foot were treated in this 10-year period, with the median age falling from 70 to 61 years and the median hospitalization from 29 to 17 days. An annual increase was observed in the highest average daily medication cost (median=RMB ￥649.5), the highest average daily examination fee (median=RMB ￥345.5) and the highest average daily bed care cost (median=RMB ￥114.7) with a median of the highest daily average treatment cost being RMB ￥191.2, which had no significant change. The proportion of self-funded patients decreased yearly from 42.2%(35/83) to less than 10%, and the proportion of the patients covered by New Rural Cooperative Medical Care by 18.1%(27/149), and the total medical cost increased. Conclusion From 2006 to 2015, the patients with diabetic foot became younger, with shorter hospital stay, increased medical cost, yearly decrease in the proportion of self-funded patients, and yearly increase in the proportion covered by New Rural Cooperative Medical Care.