Objective To investigate the correlation and the concordance of stenosis severity in patients with coronary artery disease (CAD) by physician′s visual assessment and quantitative coronary angiography (QCA). Methods Clinical data of 101 CAD patients with at least 1 lesion of ≥50% stenosis identified by coronary computed tomographic angiography (CCTA) and undergoing coronary angiography (CAG) at same period (<1 week) in our department from June 2016 to January 2017 were collected and retrospectively analyzed in this study. According to the lesion sites by CAG results, 2D-QCA software was employed to assess the coronary stenosis, and the results were analyzed for correlation with visual assessment. SPSS statistics 17.0 was used to analyze the data. Pearson linear correlation analysis was performed for correlation analysis, and Kappa test and Bland-Altman analysis for consistency test. ResultsThere were totally 164 target lesions in the 101 patients, accounting for 50.6%(83/164) in the left anterior descending branch, 18.9%(31/164) in the left circumflex branch, and 30.5%(50/164) in the right coronary artery. Pearson linear correlation analysis indicated significant positive correlation between the visual results and the QCA results (r=0.745, P<0.01). A weighted Kappa of 0.453 was found, suggesting not good enough concordance between the 2 measurements in assessment of stenosis. Bland-Altman analysis showed 4.9%(8/164) was beyond the concordance boundary, indicating unsatisfactory concordance. Conclusion There is good correlation in the assessment of coronary artery stenosis by visual assessment and QCA, but the concordance is unsatisfactory.