For the patients with moderate-grade stable coronary artery disease (CAD), it is crucial to determine whether the lesions have significant influences on distal hemodynamics of the coronary arteries (myocardial ischemia) in the process of clinical decision-making. And in these critical conditions, fractional flow reserve (FFR) is the golden standard for identifying the presence or absence of myocardial ischemia. In recent years, with the development of computational fluid dynamics (CFD), a new technology, namely FFRCT, has been developed to calculate FFR values non-invasively based on coronary CT angiography (CCTA). In this review, we elucidated the concepts and application principles of FFRCT, and summarized several current clinical trials concerning the technique, and indicated its good diagnostic performance, clinical practice, advantages, limitations and clinical application prospects.